Close-Up-Of-Wheat-Intolerant-Woman-Holding-Bread-000068881379_optIf your body is reacting to gluten in a negative way, you may experience one or more of these symptoms:


  1. Digestive issues such as bloating, gas, diarrhea, acid reflux, abdominal pain.
  2. Fatigue, brain fog.
  3. Autoimmune thyroiditis or Hashimoto’s disease.
  4. Joint pain especially if there are multiple areas either on both sides of the body or pain in joints above and below the waist.
  5. Neurologic symptoms such as feeling dizzy or feeling that you are off-balance.
  6. Headaches
  7. Mood disorders such as anxiety and depression.


Cyrex Labs, a Clinical Immunology Laboratory Specializing in Functional Immunology and Autoimmunity.  They are arguably the world’s leading laboratory in performing specialized blood tests that evaluate a patient for gluten intolerance and sensitivity.  They list a number of conditions that may warrant blood tests for the possibility of an immune mediated response against gluten.


The following types of conditions may benefit from a gluten-free diet and clinicians should consider specialized testing to determine if being gluten-free could be an adjunct of therapy to improve the patient’s immune response to a specific condition.


Cyrex Laboratories, LLC in their clinical applications guide to Antibody Array 3: Wheat/Gluten Proteome Reactivity & Autoimmunity provide the following information to physicians on the clinical use of this test:

  1. Patients that have a gut dysbiosis which appear to be resistant to standard therapy.
  2. Patients that are suspected of having intestinal mucosal damage.
  3. Patients that complain of food allergies and intolerance.
  4. Patients that complain of sensitivity to certain chemicals.
  5. Patients that present with multiple system complaints such as chronic fatigue syndrome and fibromyalgia.
  6. Patients that suffer from abnormal immune cell counts and function.
  7. Patients that may have problems with blood – brain barrier permeability, depression, and neuro- autoimmunity.


  1. Narrow autoimmune patients that need to be considered for testing:
  • Thyroiditis
  • Arthritis
  • Myocarditis
  • Dermatitis
  • Endocrinopathy
  • Polyendocrinopathy
  • Osteoarthritis
  • Pernicious anemia
  • Other